PARP12

Across TCGA cell cohorts, PARP12 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,841 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PARP12-associated GO terms across cancer lineages are Antigen processing and presentation of exogenous peptide antigen via MHC class Ib, Cytoplasmic pattern recognition receptor signaling pathway, and Negative regulation of response to biotic stimulus. Each is linked with PARP12 in more than 14 cancer types. Because this analysis shows association rather than direction, both PARP12-to-partner and partner-to-PARP12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Antigen processing and presentation of exogenous peptide antigen via MHC class Ib grouped by PARP12-low versus PARP12-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP12→partner) and Y-score (partner→PARP12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Antigen processing and presentation of exogenous peptide antigen via MHC class Ib →	+0.266	+1.001	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Cytoplasmic pattern recognition receptor signaling pathway →	+0.112	+1.658	<.001	<.001	3	14
BREAST	Negative regulation of response to biotic stimulus →	+0.082	+1.109	<.001	<.001	3	14
BONE	Positive regulation of protein binding →	+0.114	+1.172	.001	.001	3	14
UPPER_AERODIGESTIVE_TRACT	Cytosol to endoplasmic reticulum transport →	+0.228	+1.391	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Negative regulation of viral process →	+0.138	+1.220	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,841 associations by consensus.

Antigen processing and presentation of exogenous peptide antigen via MHC class Ib by PARP12 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →