PARP12

Across TCGA cell cohorts, PARP12 mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible PARP12-associated genes across cancer lineages are CCDC172, OR51I2, and CRYGC. Each is linked with PARP12 in more than 1 cancer types. Because this analysis shows association rather than direction, both PARP12-to-partner and partner-to-PARP12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC172 grouped by PARP12-low versus PARP12-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP12→partner) and Y-score (partner→PARP12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CCDC172 →	+0.639	+5.209	<.001	.005	3	2
LUNG_SCLC	OR51I2 →	+0.073	+3.898	<.001	.005	3	2
BLOOD_Leukemia	CRYGC →	+0.020	+4.384	<.001	.006	3	2
URINARY_TRACT	TARM1 →	+0.026	+5.087	<.001	.004	3	1
KIDNEY	CATSPER4 →	+0.013	+5.000	<.001	.005	3	1
LARGE_INTESTINE	MAGEB4 →	+0.016	+4.415	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

CCDC172 by PARP12 expression — BLOOD_Lymphoma

Explore this box plot interactively →