PARP11

Across TCGA cell cohorts, PARP11 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,845 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PARP11-associated GO terms across cancer lineages are Negative regulation of organelle assembly, DNA-templated transcription initiation, and Transcription initiation at RNA polymerase II promoter. Each is linked with PARP11 in more than 11 cancer types. Because this analysis shows association rather than direction, both PARP11-to-partner and partner-to-PARP11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of organelle assembly grouped by PARP11-low versus PARP11-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP11→partner) and Y-score (partner→PARP11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of organelle assembly →	+0.072	+1.095	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	DNA-templated transcription initiation →	+0.078	+0.870	.002	.001	3	12
UPPER_AERODIGESTIVE_TRACT	Transcription initiation at RNA polymerase II promoter →	+0.084	+0.992	<.001	<.001	3	11
LARGE_INTESTINE	Golgi vesicle transport →	+0.051	+0.784	<.001	.001	3	11
BLOOD_Lymphoma	Regulation of nucleotide-excision repair →	+0.110	+1.116	<.001	<.001	3	11
SOFT_TISSUE	Regulation of chromosome organization →	+0.076	+0.959	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,845 associations by consensus.

Negative regulation of organelle assembly by PARP11 expression — SOFT_TISSUE

Explore this box plot interactively →