PARP1

Across TCGA patient cohorts, PARP1 protein abundance is significantly associated with the RNA expression of many other genes, with 19,689 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PARP1-associated genes across cancer lineages are NUF2, TAF1A, and GNPAT. Each is linked with PARP1 in more than 9 cancer types. Because this analysis shows association rather than direction, both PARP1-to-partner and partner-to-PARP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PARP1 versus NUF2 in UCEC, with a Pearson correlation of 0.65.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP1→partner) and Y-score (partner→PARP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NUF2 →	+1.177	+0.389	<.001	<.001	3	10
UCEC	TAF1A →	+0.754	+0.368	<.001	<.001	3	10
UCEC	GNPAT →	+0.690	+0.365	<.001	<.001	3	9
LSCC	DARS2 →	+0.640	+0.421	<.001	<.001	3	9
BRCA	NEK2 →	+1.154	+0.417	<.001	<.001	3	9
UCEC	DKC1 →	+0.670	+0.247	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,689 associations by consensus.

PARP1 vs NUF2 — UCEC

Explore this scatter interactively →