PARP1

Across TCGA patient cohorts, PARP1 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARP1-associated genes across cancer lineages are FASN, PRAS40_pT246, and Rab25. Each is linked with PARP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PARP1-to-partner and partner-to-PARP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by PARP1-low versus PARP1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP1→partner) and Y-score (partner→PARP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FASN →	+0.529	+2.815	.013	.036	3	3
UCEC	PRAS40_pT246 →	+0.119	+2.807	.041	.003	3	2
UCEC	Rab25 →	-0.340	-1.678	.002	.021	3	2
UCEC	Annexin_VII →	-0.145	-1.807	.002	.004	3	2
UCEC	STAT3_pY705 →	-0.458	-2.523	<.001	<.001	3	2
UCEC	AR →	-0.273	-1.415	.031	.043	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

FASN by PARP1 expression — COAD

Explore this box plot interactively →