PARP1

Across TCGA cell cohorts, PARP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,059 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PARP1-associated GO terms across cancer lineages are DNA strand elongation involved in DNA replication, Lagging strand elongation, and Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery. Each is linked with PARP1 in more than 19 cancer types. Because this analysis shows association rather than direction, both PARP1-to-partner and partner-to-PARP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA strand elongation involved in DNA replication grouped by PARP1-low versus PARP1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP1→partner) and Y-score (partner→PARP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA strand elongation involved in DNA replication →	+0.193	+1.959	<.001	<.001	3	20
SOFT_TISSUE	Lagging strand elongation →	+0.138	+0.976	<.001	<.001	3	20
LUNG_NSCLC_LUSC	Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery →	+0.156	+0.888	<.001	<.001	3	19
BONE	DNA integrity checkpoint signaling →	+0.101	+1.257	<.001	.001	3	19
SOFT_TISSUE	Nucleobase biosynthetic process →	+0.156	+1.583	<.001	<.001	3	19
BREAST	Nucleosome disassembly →	+0.165	+1.199	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,059 associations by consensus.

DNA strand elongation involved in DNA replication by PARP1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →