PARP1

Across TCGA cell cohorts, PARP1 mutation is significantly associated with the RNA expression of many other genes, with 289 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PARP1-associated genes across cancer lineages are SMR3B, HMGB4, and KRTAP13-2. Each is linked with PARP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PARP1-to-partner and partner-to-PARP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMR3B grouped by PARP1-low versus PARP1-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP1→partner) and Y-score (partner→PARP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SMR3B →	+0.746	+5.000	<.001	.006	3	1
PANCREAS	HMGB4 →	+0.033	+5.000	<.001	.006	3	1
PANCREAS	KRTAP13-2 →	+0.042	+5.000	<.001	.006	3	1
PANCREAS	DHRS7C →	+0.065	+5.000	<.001	.006	3	1
PANCREAS	ZIM2 →	+0.035	+5.000	<.001	.006	3	1
LARGE_INTESTINE	CBY1 →	+0.761	+3.482	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 289 associations by consensus.

SMR3B by PARP1 expression — PANCREAS

Explore this box plot interactively →