PARN

Across TCGA patient cohorts, PARN mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARN-associated genes across cancer lineages are 4E-BP1, EGFR_pY1068, and Acetyl-a-Tubulin-Lys40. Each is linked with PARN in more than 1 cancer types. Because this analysis shows association rather than direction, both PARN-to-partner and partner-to-PARN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by PARN-low versus PARN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARN→partner) and Y-score (partner→PARN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.260	+2.199	.014	.033	3	2
UCEC	EGFR_pY1068 →	-0.316	-2.000	.001	.010	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.495	+2.594	.013	.006	3	1
UCEC	JNK_pT183_Y185 →	-0.188	-1.874	.004	.049	3	1
UCEC	JNK2 →	+0.221	+2.594	.004	.006	3	1
UCEC	Lck →	+0.159	+2.000	.044	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

4E-BP1 by PARN expression — UCEC

Explore this box plot interactively →