PARN

Across TCGA cell cohorts, PARN RNA expression is significantly associated with the go_rna of many other GO terms, with 3,819 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PARN-associated GO terms across cancer lineages are Telomerase RNA stabilization, Symbiont-mediated disruption of host cell PML body, and Poly(A)-dependent snoRNA 3'-end processing. Each is linked with PARN in more than 13 cancer types. Because this analysis shows association rather than direction, both PARN-to-partner and partner-to-PARN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Telomerase RNA stabilization grouped by PARN-low versus PARN-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PARN→partner) and Y-score (partner→PARN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Telomerase RNA stabilization →	+0.123	+0.958	<.001	<.001	3	14
BREAST	Symbiont-mediated disruption of host cell PML body →	+0.098	+0.672	<.001	<.001	3	14
BREAST	Poly(A)-dependent snoRNA 3'-end processing →	+0.132	+0.837	<.001	<.001	3	12
OESOPHAGUS	Regulation of protection from non-homologous end joining at telomere →	-0.117	-0.386	.001	.004	3	11
OESOPHAGUS	Negative regulation of protection from non-homologous end joining at telomere →	-0.117	-0.386	.001	.004	3	11
OESOPHAGUS	Telomeric DNA-containing double minutes formation →	-0.117	-0.386	.001	.004	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,819 associations by consensus.

Telomerase RNA stabilization by PARN expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →