PARM1

Across TCGA patient cohorts, PARM1 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARM1-associated genes across cancer lineages are eIF4E, PCNA, and ATM. Each is linked with PARM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PARM1-to-partner and partner-to-PARM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PARM1-low versus PARM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARM1→partner) and Y-score (partner→PARM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.235	+3.087	.005	<.001	3	2
UCEC	PCNA →	+0.266	+3.087	.002	<.001	3	2
UCEC	ATM →	-0.499	-2.986	.006	.035	3	2
SKCM	PREX1 →	-0.275	-1.982	.031	.009	3	1
UCEC	FoxM1 →	+0.228	+2.415	.028	.003	3	1
UCEC	GATA6 →	-0.156	-3.155	.017	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

eIF4E by PARM1 expression — UCEC

Explore this box plot interactively →