PARM1

Across TCGA cell cohorts, PARM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,531 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PARM1-associated GO terms across cancer lineages are Aerobic respiration, ER-nucleus signaling pathway, and Regulation of DNA-templated transcription elongation. Each is linked with PARM1 in more than 10 cancer types. Because this analysis shows association rather than direction, both PARM1-to-partner and partner-to-PARM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Aerobic respiration grouped by PARM1-low versus PARM1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PARM1→partner) and Y-score (partner→PARM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Aerobic respiration →	+0.086	+0.575	.001	<.001	3	11
LUNG_NSCLC_LUSC	ER-nucleus signaling pathway →	+0.090	+1.980	<.001	.005	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA-templated transcription elongation →	+0.076	+0.829	<.001	<.001	3	10
BONE	Regulation of syncytium formation by plasma membrane fusion →	+0.079	+2.736	.006	.002	3	9
BONE	Protein-RNA complex organization →	+0.102	+2.759	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Cytoplasmic translation →	+0.083	+0.694	<.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,531 associations by consensus.

Aerobic respiration by PARM1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →