PARL

Across TCGA patient cohorts, PARL mutation is significantly associated with the RNA expression of many other genes, with 196 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARL-associated genes across cancer lineages are MIR1224, RN7SKP181, and RNA5SP436. Each is linked with PARL in more than 1 cancer types. Because this analysis shows association rather than direction, both PARL-to-partner and partner-to-PARL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1224 grouped by PARL-low versus PARL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARL→partner) and Y-score (partner→PARL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR1224 →	+0.330	+2.944	<.001	.001	3	2
UCEC	RN7SKP181 →	+0.094	+2.996	.003	<.001	3	2
KIRP	RNA5SP436 →	+0.248	+4.628	<.001	.007	3	2
SKCM	RNU1-31P →	+0.285	+4.513	<.001	.009	3	2
SKCM	LARP1BP3 →	+0.049	+4.594	.007	.008	3	2
LUAD	RN7SKP85 →	+0.237	+5.279	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 196 associations by consensus.

MIR1224 by PARL expression — UCEC

Explore this box plot interactively →