PARL

Across TCGA patient cohorts, PARL mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARL-associated genes across cancer lineages are EGFR_pY1173, FOXO3a_pS318_S321, and HER3_pY1289. Each is linked with PARL in more than 1 cancer types. Because this analysis shows association rather than direction, both PARL-to-partner and partner-to-PARL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1173 grouped by PARL-low versus PARL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARL→partner) and Y-score (partner→PARL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	+0.130	+2.196	.001	.034	3	1
UCEC	FOXO3a_pS318_S321 →	-0.154	-2.990	.018	.036	3	1
UCEC	HER3_pY1289 →	+0.116	+2.827	.010	.035	3	1
UCEC	Ku80 →	+0.297	+3.009	.016	.019	3	1
UCEC	MEK1 →	+0.379	+3.000	.048	.036	3	1
UCEC	Notch1 →	+0.237	+3.009	.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

EGFR_pY1173 by PARL expression — UCEC

Explore this box plot interactively →