PARL

Across TCGA cell cohorts, PARL RNA expression is significantly associated with the go_rna of many other GO terms, with 2,953 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PARL-associated GO terms across cancer lineages are Regulation of cardiolipin metabolic process, Maintenance of centrosome location, and Mitochondrial translation. Each is linked with PARL in more than 11 cancer types. Because this analysis shows association rather than direction, both PARL-to-partner and partner-to-PARL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cardiolipin metabolic process grouped by PARL-low versus PARL-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PARL→partner) and Y-score (partner→PARL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of cardiolipin metabolic process →	+0.195	+1.188	<.001	.001	3	12
LUNG_NSCLC_LUSC	Maintenance of centrosome location →	+0.153	+1.121	.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Mitochondrial translation →	+0.104	+0.803	<.001	<.001	3	8
OVARY	Maintenance of Golgi location →	+0.116	+0.762	.001	<.001	3	8
PANCREAS	[4Fe-4S] cluster assembly →	+0.126	+0.476	.004	.007	3	8
BONE	Inner mitochondrial membrane organization →	+0.076	+0.475	.004	.007	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,953 associations by consensus.

Regulation of cardiolipin metabolic process by PARL expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →