PARL

Across TCGA cell cohorts, PARL mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PARL-associated genes across cancer lineages are VSX2, OR10H2, and CNBD1. Each is linked with PARL in more than 1 cancer types. Because this analysis shows association rather than direction, both PARL-to-partner and partner-to-PARL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VSX2 grouped by PARL-low versus PARL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARL→partner) and Y-score (partner→PARL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	VSX2 →	+0.016	+2.994	.001	.006	3	1
LARGE_INTESTINE	OR10H2 →	+0.091	+3.103	<.001	.004	3	1
LARGE_INTESTINE	CNBD1 →	+0.270	+3.562	<.001	.002	3	1
LARGE_INTESTINE	KCNA4 →	+0.085	+3.217	<.001	.006	3	1
LARGE_INTESTINE	BPY2 →	+0.012	+3.700	<.001	.009	3	1
LARGE_INTESTINE	BPY2B →	+0.012	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

VSX2 by PARL expression — LARGE_INTESTINE

Explore this box plot interactively →