PARL

Across TCGA cell cohorts, PARL mutation is significantly associated with the mutation status of many other genes, with 727 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PARL-associated genes across cancer lineages are CRYZ, MSI2, and PABPC1L. Each is linked with PARL in more than 2 cancer types. Because this analysis shows association rather than direction, both PARL-to-partner and partner-to-PARL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRYZ grouped by PARL-low versus PARL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARL→partner) and Y-score (partner→PARL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CRYZ →	+2.678	+2.807	.006	.006	1	3
LARGE_INTESTINE	MSI2 →	+3.584	+3.007	.008	.008	1	3
CNS	PABPC1L →	+5.584	+4.614	<.001	<.001	1	2
CNS	ATP6V0A4 →	+5.000	+4.044	.008	.008	1	2
CNS	ASL →	+5.000	+4.044	.008	.008	1	2
LARGE_INTESTINE	PTPN4 →	+2.736	+3.208	.001	.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 727 associations by consensus.

CRYZ by PARL expression — LARGE_INTESTINE

Explore this box plot interactively →