PARGP1

Across TCGA patient cohorts, PARGP1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARGP1-associated genes across cancer lineages are FOXO3a, Gab2, and MEK1. Each is linked with PARGP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PARGP1-to-partner and partner-to-PARGP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a grouped by PARGP1-low versus PARGP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARGP1→partner) and Y-score (partner→PARGP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a →	-0.133	-2.292	.003	.034	3	1
UCEC	Gab2 →	+0.337	+2.000	.036	.032	3	1
UCEC	MEK1 →	+0.479	+3.459	.003	.005	3	1
UCEC	Notch1 →	+0.140	+2.000	.027	.032	3	1
UCEC	STAT3_pY705 →	-0.411	-2.700	<.001	.006	3	1
UCEC	Tuberin →	+0.293	+2.000	.016	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

FOXO3a by PARGP1 expression — UCEC

Explore this box plot interactively →