Across TCGA patient cohorts, PARG protein abundance is significantly associated with the RNA expression of many other genes, with 8,265 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PARG-associated genes across cancer lineages are CDK1, CUL2, and CENPA. Each is linked with PARG in more than 4 cancer types. Because this analysis shows association rather than direction, both PARG-to-partner and partner-to-PARG results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARG→partner) and Y-score (partner→PARG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CDK1 →	+0.983	+0.165	<.001	<.001	3	5
LSCC	CUL2 →	+0.398	+0.253	<.001	<.001	3	5
LUAD	CENPA →	+0.811	+0.149	<.001	<.001	3	5
UCEC	MASTL →	+0.516	+0.209	<.001	<.001	3	5
LSCC	PRXL2A →	+0.823	+0.203	<.001	<.001	3	5
UCEC	VPS26A →	+0.448	+0.188	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,265 associations by consensus.

Exploration

PARG survival (RNA) · tumor vs normal (RNA) · all PARG data types