Across TCGA patient cohorts, PARG mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARG-associated genes across cancer lineages are ASNS, EGFR_pY1068, and PDCD4. Each is linked with PARG in more than 1 cancer types. Because this analysis shows association rather than direction, both PARG-to-partner and partner-to-PARG results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARG→partner) and Y-score (partner→PARG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.652	+2.815	.002	.036	3	2
UCEC	EGFR_pY1068 →	-0.216	-1.392	.008	.019	3	2
UCEC	PDCD4 →	-0.353	-2.000	.022	.029	3	2
UCEC	C-Raf →	+0.140	+2.169	.002	.003	3	2
COAD	FASN →	+0.530	+2.815	.013	.036	3	1
COAD	GSK3-a-b →	+0.221	+2.849	.008	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Exploration

PARG survival (RNA) · tumor vs normal (RNA) · all PARG data types