PARD3B

Across TCGA patient cohorts, PARD3B mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARD3B-associated genes across cancer lineages are Caspase-7-cleavedD198, ATM, and Bax. Each is linked with PARD3B in more than 3 cancer types. Because this analysis shows association rather than direction, both PARD3B-to-partner and partner-to-PARD3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PARD3B-low versus PARD3B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARD3B→partner) and Y-score (partner→PARD3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.604	+2.824	<.001	.034	3	4
UCEC	ATM →	-0.321	-1.765	.019	.013	3	3
LUSC	Bax →	+0.192	+1.594	.028	.043	3	2
LUSC	beta-Catenin →	-0.591	-3.000	.003	.033	3	2
COAD	AMPK_alpha →	-0.212	-3.127	.017	.019	3	2
UCEC	PCNA →	+0.162	+1.222	.012	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Caspase-7-cleavedD198 by PARD3B expression — COAD

Explore this box plot interactively →