PARD3B

Across TCGA cell cohorts, PARD3B mutation is significantly associated with the RNA expression of many other genes, with 979 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PARD3B-associated genes across cancer lineages are OR14A2, SERTM2, and DCD. Each is linked with PARD3B in more than 1 cancer types. Because this analysis shows association rather than direction, both PARD3B-to-partner and partner-to-PARD3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR14A2 grouped by PARD3B-low versus PARD3B-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARD3B→partner) and Y-score (partner→PARD3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR14A2 →	+0.050	+4.115	<.001	<.001	3	2
LUNG_NSCLC_LUAD	SERTM2 →	+0.727	+3.760	<.001	.008	3	2
BLOOD_Myeloma	DCD →	+0.063	+4.807	<.001	.006	3	1
BLOOD_Myeloma	EVX2 →	+0.016	+4.807	<.001	.006	3	1
BLOOD_Myeloma	CCDC60 →	+0.033	+4.807	<.001	.006	3	1
OVARY	CABS1 →	+0.028	+3.405	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 979 associations by consensus.

OR14A2 by PARD3B expression — OVARY

Explore this box plot interactively →