PARD3

Across TCGA patient cohorts, PARD3 mutation is significantly associated with the total protein of many other genes, with 71 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARD3-associated genes across cancer lineages are Rad50, Cyclin-B1, and eEF2. Each is linked with PARD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PARD3-to-partner and partner-to-PARD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by PARD3-low versus PARD3-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARD3→partner) and Y-score (partner→PARD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Rad50 →	-0.283	-3.169	.026	.019	3	3
COAD	Cyclin-B1 →	+0.561	+3.008	.047	.019	3	3
UCEC	eEF2 →	+0.217	+1.247	.023	.038	3	3
UCEC	FoxM1 →	+0.141	+1.343	.041	.002	3	3
SKCM	PCNA →	+0.142	+2.000	.049	.027	3	3
UCEC	PDCD4 →	-0.344	-1.191	.006	.025	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

Rad50 by PARD3 expression — STAD

Explore this box plot interactively →