PARD3

Across TCGA cell cohorts, PARD3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,291 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PARD3-associated GO terms across cancer lineages are Regulation of hippo signaling, Neuropilin signaling pathway, and Schwann cell differentiation. Each is linked with PARD3 in more than 8 cancer types. Because this analysis shows association rather than direction, both PARD3-to-partner and partner-to-PARD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of hippo signaling grouped by PARD3-low versus PARD3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PARD3→partner) and Y-score (partner→PARD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of hippo signaling →	+0.060	+0.635	.006	.006	3	9
SKIN	Neuropilin signaling pathway →	+0.177	+0.884	<.001	.001	3	8
LARGE_INTESTINE	Schwann cell differentiation →	+0.077	+0.735	<.001	<.001	3	8
BREAST	Regulation of hematopoietic stem cell differentiation →	+0.082	+0.790	.001	.001	3	8
BLOOD_Myeloma	Negative regulation of peptidyl-threonine phosphorylation →	+0.243	+2.112	<.001	<.001	3	8
PANCREAS	Regulation of dephosphorylation →	+0.074	+0.699	.004	.001	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,291 associations by consensus.

Regulation of hippo signaling by PARD3 expression — BONE

Explore this box plot interactively →