PARAL1

Across TCGA pan-cancer cohorts, PARAL1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated PARAL1 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher PARAL1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PARAL1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and ESCA show a favorable association.

SKCM, BLCA, and KIRC are the cancer types where PARAL1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.454	0.248	<.001	94	view →
BLCA	DFS	Median	II,III,IV	0.544	0.684	.002	65	view →
KIRC	OS	Tertile	All	0.476	0.713	<.001	48	view →
ESCA	DFS	Median	III,IV	0.586	0.294	.001	48	view →
ACC	OS	Median	All	0.455	0.880	.005	47	view →
UVM	DFS	Tertile	All	0.107	0.769	<.001	45	view →
LIHC	DFS	Median	II,III,IV	0.317	0.573	.006	25	view →
LGG	OS	Quartile	All	0.583	0.406	.007	24	view →
UCEC	DFS	Median	IV	0.263	0.599	.016	24	view →
HNSC	OS	Quartile	IV	0.541	0.889	.005	22	view →
STAD	DFS	Median	III,IV	0.671	0.485	.010	19	view →
PAAD	DFS	Quartile	All	0.604	0.312	.017	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

PARAL1–SKCM (OS)

Open the SKCM breakdown →