PAQR8

Across TCGA patient cohorts, PAQR8 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAQR8-associated genes across cancer lineages are eIF4E, p38-MAPK_pT180_Y182, and FOXO3a_pS318_S321. Each is linked with PAQR8 in more than 2 cancer types. Because this analysis shows association rather than direction, both PAQR8-to-partner and partner-to-PAQR8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PAQR8-low versus PAQR8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAQR8→partner) and Y-score (partner→PAQR8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.156	+2.070	.032	.001	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.382	-1.678	.014	.021	3	3
UCEC	FOXO3a_pS318_S321 →	-0.119	-2.575	.005	.001	3	2
UCEC	GAPDH →	+0.440	+2.115	.018	.017	3	2
UCEC	mTOR_pS2448 →	-0.113	-1.787	.028	.026	3	2
UCEC	TFRC →	+0.468	+2.070	.010	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

eIF4E by PAQR8 expression — UCEC

Explore this box plot interactively →