PAQR8

Across TCGA cell cohorts, PAQR8 mutation is significantly associated with the mutation status of many other genes, with 2,206 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PAQR8-associated genes across cancer lineages are SCRIB, FGA, and ZBTB7A. Each is linked with PAQR8 in more than 3 cancer types. Because this analysis shows association rather than direction, both PAQR8-to-partner and partner-to-PAQR8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCRIB grouped by PAQR8-low versus PAQR8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAQR8→partner) and Y-score (partner→PAQR8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SCRIB →	+1.874	+3.700	.005	.005	1	4
BLOOD_Lymphoma	FGA →	+4.584	+4.584	.007	.007	1	3
LARGE_INTESTINE	ZBTB7A →	+2.874	+3.632	.002	.002	1	3
LARGE_INTESTINE	CFAP65 →	+1.974	+3.801	.004	.004	1	3
BLOOD_Lymphoma	AATK →	+4.584	+4.584	.007	.007	1	3
LARGE_INTESTINE	TSHZ2 →	+1.781	+3.602	.006	.006	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,206 associations by consensus.

SCRIB by PAQR8 expression — LARGE_INTESTINE

Explore this box plot interactively →