PAQR5

Across TCGA patient cohorts, PAQR5 mutation is significantly associated with the RNA expression of many other genes, with 3,109 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAQR5-associated genes across cancer lineages are RNU6-1242P, FAM219B, and PTPN11. Each is linked with PAQR5 in more than 2 cancer types. Because this analysis shows association rather than direction, both PAQR5-to-partner and partner-to-PAQR5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1242P grouped by PAQR5-low versus PAQR5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAQR5→partner) and Y-score (partner→PAQR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-1242P →	+0.948	+5.017	<.001	.009	3	3
UCEC	FAM219B →	+0.578	+3.711	<.001	<.001	3	2
UCEC	PTPN11 →	+0.760	+3.754	<.001	<.001	3	2
UCEC	MED14 →	+0.662	+3.169	<.001	<.001	3	2
UCEC	ZNF609 →	+0.504	+2.042	.002	.005	3	2
UCEC	GLRX5 →	+0.446	+3.202	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,109 associations by consensus.

RNU6-1242P by PAQR5 expression — COAD

Explore this box plot interactively →