PAQR5

Across TCGA cell cohorts, PAQR5 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PAQR5-associated genes across cancer lineages are DEFA4 and BPIFA1. Each is linked with PAQR5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAQR5-to-partner and partner-to-PAQR5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA4 grouped by PAQR5-low versus PAQR5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAQR5→partner) and Y-score (partner→PAQR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEFA4 →	+0.040	+5.022	<.001	.002	3	1
LARGE_INTESTINE	BPIFA1 →	+0.191	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

DEFA4 by PAQR5 expression — LARGE_INTESTINE

Explore this box plot interactively →