Across TCGA patient cohorts, PAPSS2 RNA expression is significantly associated with the protein abundance of many other proteins, with 19,412 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PAPSS2-associated proteins across cancer lineages are PDGFRB, DAB2_S723, and RAI14. Each is linked with PAPSS2 in more than 6 cancer types. Because this analysis shows association rather than direction, both PAPSS2-to-partner and partner-to-PAPSS2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPSS2→partner) and Y-score (partner→PAPSS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PDGFRB →	+0.592	+1.100	<.001	<.001	3	7
OV	DAB2_S723 →	+1.060	+0.877	.001	.002	3	7
OV	RAI14 →	+0.343	+0.920	.001	<.001	3	6
OV	NNMT →	+1.283	+1.008	<.001	<.001	3	6
BRCA	P3H1 →	+0.559	+1.210	<.001	<.001	3	6
GBM	SEC24D →	+0.371	+0.596	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,412 associations by consensus.

Exploration

PAPSS2 survival (RNA) · tumor vs normal (RNA) · all PAPSS2 data types