Across TCGA patient cohorts, PAPSS2 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAPSS2-associated genes across cancer lineages are ATM, Caspase-8, and EGFR_pY1068. Each is linked with PAPSS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAPSS2-to-partner and partner-to-PAPSS2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPSS2→partner) and Y-score (partner→PAPSS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.370	-2.584	.018	.010	3	2
UCEC	Caspase-8 →	-0.197	-2.973	.023	<.001	3	2
UCEC	EGFR_pY1068 →	-0.244	-3.584	.005	.002	3	1
UCEC	EGFR →	-0.169	-1.848	.002	.049	3	1
UCEC	eIF4E →	+0.147	+1.736	.045	.007	3	1
UCEC	eIF4G →	+0.294	+1.736	.006	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Exploration

PAPSS2 survival (RNA) · tumor vs normal (RNA) · all PAPSS2 data types