Across TCGA cell cohorts, PAPSS2 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PAPSS2-associated genes across cancer lineages are ACOD1, CRYGD, and CRYGB. Each is linked with PAPSS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAPSS2-to-partner and partner-to-PAPSS2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPSS2→partner) and Y-score (partner→PAPSS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ACOD1 →	+0.005	+4.285	<.001	.007	3	1
STOMACH	CRYGD →	+0.172	+4.285	<.001	.007	3	1
STOMACH	CRYGB →	+0.042	+4.285	<.001	.007	3	1
STOMACH	FIGLA →	+0.190	+4.285	<.001	.007	3	1
STOMACH	ZNF735 →	+0.012	+4.285	<.001	.007	3	1
BLOOD_Leukemia	PRND →	+0.009	+3.874	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

PAPSS2 survival (RNA) · tumor vs normal (RNA) · all PAPSS2 data types