PAPSS1

Across TCGA patient cohorts, PAPSS1 mutation is significantly associated with the RNA expression of many other genes, with 3,379 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAPSS1-associated genes across cancer lineages are RPL30P5, RNA5SP422, and COX15. Each is linked with PAPSS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PAPSS1-to-partner and partner-to-PAPSS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL30P5 grouped by PAPSS1-low versus PAPSS1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPSS1→partner) and Y-score (partner→PAPSS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPL30P5 →	+0.099	+3.656	.006	.006	3	3
UCEC	RNA5SP422 →	+0.584	+1.905	<.001	.001	3	3
UCEC	COX15 →	+0.429	+3.008	<.001	<.001	3	2
UCEC	CHEK1 →	+0.764	+2.158	<.001	<.001	3	2
UCEC	C12orf45 →	+0.361	+2.962	.007	<.001	3	2
UCEC	SRFBP1 →	+0.464	+1.931	.007	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,379 associations by consensus.

RPL30P5 by PAPSS1 expression — LUAD

Explore this box plot interactively →