PAPSS1

Across TCGA cell cohorts, PAPSS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,803 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PAPSS1-associated GO terms across cancer lineages are Regulation of smoothened signaling pathway, Protein-DNA complex organization, and Epigenetic regulation of gene expression. Each is linked with PAPSS1 in more than 11 cancer types. Because this analysis shows association rather than direction, both PAPSS1-to-partner and partner-to-PAPSS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of smoothened signaling pathway grouped by PAPSS1-low versus PAPSS1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPSS1→partner) and Y-score (partner→PAPSS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of smoothened signaling pathway →	+0.087	+1.204	<.001	.001	3	12
BONE	Protein-DNA complex organization →	+0.083	+1.026	<.001	.001	3	11
OVARY	Epigenetic regulation of gene expression →	+0.064	+0.880	<.001	.003	3	11
OVARY	Ribonucleoside triphosphate biosynthetic process →	+0.090	+0.944	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Regulation of sister chromatid segregation →	+0.108	+0.768	.001	.004	2	11
BONE	Protein-DNA complex assembly →	+0.074	+0.993	.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,803 associations by consensus.

Regulation of smoothened signaling pathway by PAPSS1 expression — LUNG_NSCLC_LUSC

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