PAPSS1

Across TCGA cell cohorts, PAPSS1 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PAPSS1-associated genes across cancer lineages are WFDC6, GCM2, and PLVAP. Each is linked with PAPSS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAPSS1-to-partner and partner-to-PAPSS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WFDC6 grouped by PAPSS1-low versus PAPSS1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPSS1→partner) and Y-score (partner→PAPSS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	WFDC6 →	+0.068	+5.472	<.001	<.001	3	1
LARGE_INTESTINE	GCM2 →	+0.048	+2.657	.002	.007	3	1
LARGE_INTESTINE	PLVAP →	+0.231	+3.539	<.001	.004	3	1
LARGE_INTESTINE	LHCGR →	+0.025	+2.882	.005	.005	3	1
LARGE_INTESTINE	SLC35G3 →	+0.006	+2.882	<.001	.005	3	1
LARGE_INTESTINE	WDR87 →	+0.019	+3.353	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

WFDC6 by PAPSS1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →