PAPPA2

Across TCGA patient cohorts, PAPPA2 protein abundance is significantly associated with the RNA expression of many other genes, with 10,512 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PAPPA2-associated genes across cancer lineages are MINDY4, CTSG, and PAPLN. Each is linked with PAPPA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAPPA2-to-partner and partner-to-PAPPA2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PAPPA2 versus MINDY4 in CCRCC, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPPA2→partner) and Y-score (partner→PAPPA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	MINDY4 →	+0.469	+0.790	<.001	.006	3	2
CCRCC	CTSG →	+1.108	+0.923	.001	.005	3	1
CCRCC	PAPLN →	+0.716	+0.729	<.001	<.001	3	1
CCRCC	RABGGTA →	+0.384	+0.813	.001	<.001	3	1
CCRCC	MTHFSD →	+0.202	+0.701	.007	<.001	3	1
CCRCC	TOX3 →	+0.722	+0.786	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,512 associations by consensus.

PAPPA2 vs MINDY4 — CCRCC

Explore this scatter interactively →