PAPPA2

Across TCGA patient cohorts, PAPPA2 mutation is significantly associated with the RNA expression of many other genes, with 8,491 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAPPA2-associated genes across cancer lineages are COQ3, SLC25A33, and ZWINT. Each is linked with PAPPA2 in more than 6 cancer types. Because this analysis shows association rather than direction, both PAPPA2-to-partner and partner-to-PAPPA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COQ3 grouped by PAPPA2-low versus PAPPA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPPA2→partner) and Y-score (partner→PAPPA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COQ3 →	+0.358	+1.496	<.001	<.001	3	7
UCEC	SLC25A33 →	+0.434	+1.773	<.001	<.001	3	6
UCEC	ZWINT →	+0.712	+2.064	<.001	<.001	3	6
UCEC	EMCN →	-0.409	-1.679	<.001	.001	3	6
STAD	SDHB →	+0.372	+2.502	.003	.001	3	6
UCEC	CLDN5 →	-0.541	-1.927	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,491 associations by consensus.

COQ3 by PAPPA2 expression — UCEC

Explore this box plot interactively →