PAPPA2

Across TCGA patient cohorts, PAPPA2 mutation is significantly associated with the total protein of many other genes, with 72 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAPPA2-associated genes across cancer lineages are 4E-BP1, Caspase-7-cleavedD198, and Cyclin-E2. Each is linked with PAPPA2 in more than 5 cancer types. Because this analysis shows association rather than direction, both PAPPA2-to-partner and partner-to-PAPPA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by PAPPA2-low versus PAPPA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPPA2→partner) and Y-score (partner→PAPPA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.302	+2.247	<.001	.001	3	6
COAD	Caspase-7-cleavedD198 →	+0.934	+1.786	<.001	.001	3	5
UCEC	Cyclin-E2 →	+0.121	+1.363	.007	.008	3	4
BLCA	PRDX1 →	+0.225	+2.820	.031	.035	3	4
SKCM	Caveolin-1 →	-0.385	-0.906	.003	.024	3	4
STAD	cIAP →	+0.117	+2.115	.039	.017	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

4E-BP1 by PAPPA2 expression — UCEC

Explore this box plot interactively →