PAPPA2

Across TCGA cell cohorts, PAPPA2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,209 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PAPPA2-associated GO terms across cancer lineages are Response to endoplasmic reticulum stress, Endosomal transport, and Positive regulation of post-translational protein modification. Each is linked with PAPPA2 in more than 8 cancer types. Because this analysis shows association rather than direction, both PAPPA2-to-partner and partner-to-PAPPA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to endoplasmic reticulum stress grouped by PAPPA2-low versus PAPPA2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPPA2→partner) and Y-score (partner→PAPPA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Response to endoplasmic reticulum stress →	+0.056	+1.005	.001	.009	3	9
BONE	Endosomal transport →	+0.051	+1.438	.004	.007	3	7
BLOOD_Lymphoma	Positive regulation of post-translational protein modification →	+0.044	+0.121	<.001	.004	3	7
BONE	Establishment of protein localization to plasma membrane →	+0.111	+1.119	<.001	.003	3	6
BONE	Response to unfolded protein →	+0.076	+0.998	<.001	.009	3	6
SOFT_TISSUE	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress →	+0.064	+0.411	<.001	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,209 associations by consensus.

Response to endoplasmic reticulum stress by PAPPA2 expression — BONE

Explore this box plot interactively →