PAPPA2

Across TCGA cell cohorts, PAPPA2 mutation is significantly associated with the RNA expression of many other genes, with 1,125 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PAPPA2-associated genes across cancer lineages are TMSB4Y, SYN3, and RPF1. Each is linked with PAPPA2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PAPPA2-to-partner and partner-to-PAPPA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMSB4Y grouped by PAPPA2-low versus PAPPA2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPPA2→partner) and Y-score (partner→PAPPA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TMSB4Y →	+0.343	+1.866	.001	.003	3	4
OESOPHAGUS	SYN3 →	+0.673	+3.285	.001	.003	3	3
LARGE_INTESTINE	RPF1 →	+0.534	+2.546	.001	.001	3	3
LARGE_INTESTINE	CYP4V2 →	+0.934	+2.584	<.001	.002	3	3
LARGE_INTESTINE	NFXL1 →	+0.515	+2.000	.004	.004	3	3
URINARY_TRACT	RBAK →	+0.696	+3.000	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,125 associations by consensus.

TMSB4Y by PAPPA2 expression — SKIN

Explore this box plot interactively →