PAPPA2

Across TCGA cell cohorts, PAPPA2 mutation is significantly associated with the mutation status of many other genes, with 3,243 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PAPPA2-associated genes across cancer lineages are MUC5B, MKI67, and HYDIN. Each is linked with PAPPA2 in more than 7 cancer types. Because this analysis shows association rather than direction, both PAPPA2-to-partner and partner-to-PAPPA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MUC5B grouped by PAPPA2-low versus PAPPA2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPPA2→partner) and Y-score (partner→PAPPA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MUC5B →	+1.977	+2.637	.008	.008	1	8
CNS	MKI67 →	+3.470	+5.048	<.001	<.001	1	6
SOFT_TISSUE	HYDIN →	+4.562	+3.329	.003	.003	1	6
CNS	PLEC →	+2.108	+3.862	.007	.007	1	6
OVARY	DYNC1H1 →	+2.920	+2.611	<.001	<.001	1	6
OVARY	CUBN →	+2.183	+1.932	.007	.007	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,243 associations by consensus.

MUC5B by PAPPA2 expression — SOFT_TISSUE

Explore this box plot interactively →