PAPOLG

Across TCGA patient cohorts, PAPOLG protein abundance is significantly associated with the RNA expression of many other genes, with 13,771 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PAPOLG-associated genes across cancer lineages are CENPA, MSH6, and RAD51AP1. Each is linked with PAPOLG in more than 5 cancer types. Because this analysis shows association rather than direction, both PAPOLG-to-partner and partner-to-PAPOLG results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PAPOLG versus CENPA in HNSC, with a Pearson correlation of 0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPOLG→partner) and Y-score (partner→PAPOLG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CENPA →	+0.989	+0.283	<.001	.002	3	6
OV	MSH6 →	+0.742	+0.288	<.001	.002	3	6
BRCA	RAD51AP1 →	+0.878	+0.379	.001	<.001	3	5
BRCA	ESPL1 →	+0.995	+0.379	<.001	<.001	3	5
UCEC	CENPE →	+0.919	+0.299	.001	.001	3	5
BRCA	KIFC1 →	+1.280	+0.458	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,771 associations by consensus.

PAPOLG vs CENPA — HNSC

Explore this scatter interactively →