PAPOLG

Across TCGA patient cohorts, PAPOLG mutation is significantly associated with the RNA expression of many other genes, with 3,683 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAPOLG-associated genes across cancer lineages are KRTAP9-2, RN7SL98P, and LINC02619. Each is linked with PAPOLG in more than 2 cancer types. Because this analysis shows association rather than direction, both PAPOLG-to-partner and partner-to-PAPOLG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP9-2 grouped by PAPOLG-low versus PAPOLG-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPOLG→partner) and Y-score (partner→PAPOLG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	KRTAP9-2 →	+0.188	+4.285	<.001	.003	3	3
COAD	RN7SL98P →	+0.164	+4.371	<.001	<.001	3	3
CESC	LINC02619 →	+0.100	+5.812	<.001	.003	3	2
UCEC	NUDT18 →	+0.449	+1.648	.002	.001	3	2
UCEC	CCL4 →	+1.031	+2.120	<.001	<.001	3	2
UCEC	CCL18 →	+1.057	+1.637	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,683 associations by consensus.

KRTAP9-2 by PAPOLG expression — LUAD

Explore this box plot interactively →