PAPOLG

Across TCGA patient cohorts, PAPOLG mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAPOLG-associated genes across cancer lineages are Caspase-7-cleavedD198, FoxM1, and JNK_pT183_Y185. Each is linked with PAPOLG in more than 2 cancer types. Because this analysis shows association rather than direction, both PAPOLG-to-partner and partner-to-PAPOLG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PAPOLG-low versus PAPOLG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPOLG→partner) and Y-score (partner→PAPOLG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.611	+2.827	.001	<.001	3	3
UCEC	FoxM1 →	+0.175	+1.836	.031	.001	3	2
UCEC	JNK_pT183_Y185 →	-0.174	-1.571	<.001	.005	3	2
UCEC	MEK1 →	+0.435	+2.432	<.001	<.001	3	2
UCEC	Annexin-1 →	+0.612	+2.604	<.001	<.001	3	2
UCEC	Rictor_pT1135 →	-0.067	-1.137	.037	.041	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Caspase-7-cleavedD198 by PAPOLG expression — UCEC

Explore this box plot interactively →