PAPOLG

Across TCGA cell cohorts, PAPOLG mutation is significantly associated with the RNA expression of many other genes, with 962 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PAPOLG-associated genes across cancer lineages are SMIM31, DDX49, and GID4. Each is linked with PAPOLG in more than 1 cancer types. Because this analysis shows association rather than direction, both PAPOLG-to-partner and partner-to-PAPOLG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM31 grouped by PAPOLG-low versus PAPOLG-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPOLG→partner) and Y-score (partner→PAPOLG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SMIM31 →	+0.020	+4.013	<.001	<.001	3	2
LARGE_INTESTINE	DDX49 →	+0.520	+4.129	<.001	<.001	3	2
LARGE_INTESTINE	GID4 →	+0.546	+2.652	<.001	.001	3	2
LARGE_INTESTINE	PNPLA6 →	+0.614	+2.265	<.001	.001	3	2
LARGE_INTESTINE	MSH4 →	+0.259	+2.357	<.001	<.001	3	2
PANCREAS	SMR3B →	+0.347	+3.584	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 962 associations by consensus.

SMIM31 by PAPOLG expression — BLOOD_Leukemia

Explore this box plot interactively →