PAPOLG

Across TCGA cell cohorts, PAPOLG mutation is significantly associated with the mutation status of many other genes, with 5,080 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PAPOLG-associated genes across cancer lineages are PARP1, SEC16B, and CCDC33. Each is linked with PAPOLG in more than 3 cancer types. Because this analysis shows association rather than direction, both PAPOLG-to-partner and partner-to-PAPOLG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PARP1 grouped by PAPOLG-low versus PAPOLG-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPOLG→partner) and Y-score (partner→PAPOLG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PARP1 →	+4.187	+5.000	.008	.008	1	4
OVARY	SEC16B →	+5.217	+4.562	<.001	<.001	1	4
BLOOD_Leukemia	CCDC33 →	+3.662	+3.523	<.001	<.001	1	4
LUNG_SCLC	TTBK1 →	+3.437	+3.437	.006	.006	1	4
BLOOD_Leukemia	MYO5B →	+2.662	+3.544	<.001	<.001	1	4
BLOOD_Leukemia	BUB1 →	+3.662	+3.285	.004	.004	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,080 associations by consensus.

PARP1 by PAPOLG expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →