Across TCGA patient cohorts, PAPOLB mutation is significantly associated with the RNA expression of many other genes, with 4,189 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAPOLB-associated genes across cancer lineages are PHF5A, OIP5, and DGUOK. Each is linked with PAPOLB in more than 2 cancer types. Because this analysis shows association rather than direction, both PAPOLB-to-partner and partner-to-PAPOLB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPOLB→partner) and Y-score (partner→PAPOLB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PHF5A →	+0.523	+2.169	<.001	<.001	3	3
UCEC	OIP5 →	+0.725	+3.643	<.001	<.001	3	3
UCEC	DGUOK →	+0.247	+2.098	.004	.002	3	3
UCEC	PPCDC →	+0.414	+1.860	<.001	<.001	3	3
READ	LINC02348 →	+0.596	+4.361	<.001	.006	3	3
UCEC	PRC1 →	+0.582	+1.538	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,189 associations by consensus.

Exploration

PAPOLB survival (RNA) · tumor vs normal (RNA) · all PAPOLB data types