Across TCGA cell cohorts, PAPOLB mutation is significantly associated with the RNA expression of many other genes, with 221 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PAPOLB-associated genes across cancer lineages are CEP76, C1QBP, and RNGTT. Each is linked with PAPOLB in more than 1 cancer types. Because this analysis shows association rather than direction, both PAPOLB-to-partner and partner-to-PAPOLB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPOLB→partner) and Y-score (partner→PAPOLB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CEP76 →	+0.804	+3.364	<.001	.002	3	1
LARGE_INTESTINE	C1QBP →	+0.823	+3.451	<.001	.002	3	1
LARGE_INTESTINE	RNGTT →	+0.531	+3.364	.003	.002	3	1
LARGE_INTESTINE	PPP2R5D →	+0.625	+3.064	.003	.009	3	1
LARGE_INTESTINE	TTC33 →	+0.643	+3.364	.003	.002	3	1
LARGE_INTESTINE	MRPS15 →	+0.454	+3.082	.004	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 221 associations by consensus.

Exploration

PAPOLB survival (RNA) · tumor vs normal (RNA) · all PAPOLB data types