PAPOLA

Across TCGA pan-cancer cohorts, PAPOLA mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PAPOLA data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PAPOLA mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PAPOLA expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

HNSC, LSCC, and LUAD are the cancer types where PAPOLA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.185	0.810	.006	30	view →
LSCC	DFS	Quartile	II,III,IV	0.939	0.527	.011	14	view →
LUAD	OS	Median	All	0.876	0.618	.012	11	view →
PDAC	DFS	Tertile	IV	0.752	0.203	.024	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PAPOLA–HNSC (DFS)

Open the HNSC breakdown →