PAPOLA

Across TCGA patient cohorts, PAPOLA protein abundance is significantly associated with the RNA expression of many other genes, with 12,029 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PAPOLA-associated genes across cancer lineages are VRK1, TMPO, and TDP1. Each is linked with PAPOLA in more than 8 cancer types. Because this analysis shows association rather than direction, both PAPOLA-to-partner and partner-to-PAPOLA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PAPOLA versus VRK1 in OV, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPOLA→partner) and Y-score (partner→PAPOLA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	VRK1 →	+0.831	+0.414	<.001	<.001	3	9
HNSC	TMPO →	+1.031	+0.267	<.001	<.001	3	9
OV	TDP1 →	+0.517	+0.291	<.001	.001	3	9
COAD	CDCA4 →	+0.713	+0.234	<.001	<.001	3	8
HNSC	AURKB →	+1.182	+0.259	<.001	<.001	3	7
HNSC	FKBP3 →	+0.714	+0.175	.002	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,029 associations by consensus.

PAPOLA vs VRK1 — OV

Explore this scatter interactively →