PAPOLA

Across TCGA cell cohorts, PAPOLA RNA expression is significantly associated with the go_rna of many other GO terms, with 3,819 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PAPOLA-associated GO terms across cancer lineages are Monoubiquitinated protein deubiquitination, Double-strand break repair via homologous recombination, and Recombinational repair. Each is linked with PAPOLA in more than 18 cancer types. Because this analysis shows association rather than direction, both PAPOLA-to-partner and partner-to-PAPOLA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Monoubiquitinated protein deubiquitination grouped by PAPOLA-low versus PAPOLA-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPOLA→partner) and Y-score (partner→PAPOLA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Monoubiquitinated protein deubiquitination →	+0.132	+0.804	<.001	<.001	3	19
LUNG_SCLC	Double-strand break repair via homologous recombination →	+0.078	+0.646	<.001	<.001	3	15
LUNG_SCLC	Recombinational repair →	+0.080	+0.667	<.001	<.001	3	15
BREAST	Positive regulation of cell cycle process →	+0.085	+0.488	<.001	.004	3	15
BREAST	Epigenetic regulation of gene expression →	+0.067	+0.640	<.001	<.001	3	15
LUNG_SCLC	Heterochromatin organization →	+0.067	+0.643	<.001	.002	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,819 associations by consensus.

Monoubiquitinated protein deubiquitination by PAPOLA expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →